Pantetein-fosfat adenililtransferaza
Pantetein-fosfat adenililtransferaza (EC 2.7.7.3, defosfo-KoA pirofosforilaza, pantetein fosfat adenililtransferaza, defosfo-koenzim A pirofosforilaza, 3'-defosfo-KoA pirofosforilaza) je enzim sa sistematskim imenom ATP:pantetein-4'-fosfat adenililtransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Pantetein-fosfat adenililtransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.7.7.3 | ||||||||
| CAS broj | 9026-99-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Enzim iz nekoliko bakterija (e.g. Escherichia coli, Bacillus subtilis i Haemophilus influenzae) je bifunkcionalan.
Reference uredi
- ↑ Hoagland, M.B. and Novelli, G.D. (1954). „Biosynthesis of coenzyme A from phosphopantetheine and pantetheine from pantothenate”. J. Biol. Chem. 207: 767-773. PMID 13163064.
- ↑ Novelli, G.D. (1953). „Enzymatic synthesis and structure of CoA”. Fed. Proc. 12: 675-682. PMID 13107738.
- ↑ Martin, D.P. and Drueckhammer, D.G. (1993). „Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase”. Biochem. Biophys. Res. Commun. 192: 1155-1161. PMID 8389542.
- ↑ Geerlof, A., Lewendon, A. and Shaw, W.V. (1999). „Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli”. J. Biol. Chem. 274: 27105-27111. PMID 10480925.
- ↑ Izard, T., Geerlof, A., Lewendon, A. and Barker, J.J. (1999). „Cubic crystals of phosphopantetheine adenylyltransferase from Escherichiacoli”. Acta Crystallogr. D Biol. Crystallogr. 55: 1226-1228. PMID 10329792.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.