Org 37,684

Org 37,684
(IUPAC) ime
	(3S)-3-[(2,3-dihidro-5-metoksi-1H-inden-4-il)oksi]pirolidin
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	9794656
Hemijski podaci
Formula	C14H19NO2
Mol. masa	233,305 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C14H19NO2/c1-16-13-6-5-10-3-2-4-12(10)14(13)17-11-7-8-15-9-11/h5-6,11,15H,2-4,7-9H2,1H3 ; Key: QDJAYXYEXHVXJV-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	nije kontrolisan

Org 37,684 je lek koji deluje kao potentan i selektivni agonist za 5-HT₂ receptorsku familiju, sa najvećim afinitetom za 5-HT_2C i nižim za 5-HT_2B podtipove.^[3]^[4] On manifestuje anoreksne efekte u životinjskim studijama i bio je istraživan kao potencijan lek za mršavljenje ljudi.^[5]

Vidi još uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Adams, D.; Duncton, M. (2001). „Efficient Synthesis of the 5-HT2C Receptor Agonist, ORG 37684”. Synthetic Communications 31 (13): 2029. DOI:10.1081/SCC-100104420.
↑ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 2004;370:114-123. DOI:10.1007/s00210-004-0951-4 PMID 15322733
↑ Schreiber R, De Vry J. Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Progress in Neuropsychopharmacology and Biological Psychiatry. 2002 Apr;26(3):441-9. PMID 11999893

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