OR51E1
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Olfaktorni receptor 51E1 je protein koji je kod ljudi kodiran OR51E1 genom.[1]
| Olfaktorni receptor, familija 51, potfamilija E, član 1 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | OR51E1; D-GPCR; GPR136; GPR164; OR51E1P; OR52A3P; POGR; PSGR2 | ||||||||||
| Vanjski ID | OMIM: 611267 MGI: 3030392 HomoloGene: 17503 IUPHAR: GeneCards: OR51E1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 143503 | 259097 | |||||||||
| Ensembl | ENSG00000180785 | ENSMUSG00000070423 | |||||||||
| UniProt | Q8TCB6 | Q8VGZ7 | |||||||||
| RefSeq (mRNA) | NM_152430.3 | NM_147093.3 | |||||||||
| RefSeq (protein) | NP_689643.2 | NP_667304.1 | |||||||||
| Lokacija (UCSC) | Chr 11: 4.66 - 4.68 Mb | Chr 7: 102.7 - 102.71 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[1]
Reference uredi
Literatura uredi
- Wang J, Weng J, Cai Y, et al. (2006). „The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase”. Prostate 66 (8): 847–57. DOI:10.1002/pros.20389. PMID 16491480.
- Weng J, Wang J, Hu X, et al. (2007). „PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer”. Int. J. Cancer 118 (6): 1471–80. DOI:10.1002/ijc.21527. PMID 16206286.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Weigle B, Fuessel S, Ebner R, et al. (2004). „D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate”. Biochem. Biophys. Res. Commun. 322 (1): 239–49. DOI:10.1016/j.bbrc.2004.07.106. PMID 15313197.
- Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family”. Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. DOI:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Vanti WB, Nguyen T, Cheng R, et al. (2003). „Novel human G-protein-coupled receptors”. Biochem. Biophys. Res. Commun. 305 (1): 67–71. DOI:10.1016/S0006-291X(03)00709-5. PMID 12732197.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). „Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence” (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098.