Nicergolin

Nicergolin
(IUPAC) ime
	[(8β)-10-metoksi-1,6-dimetilergolin-8-il]metil 5-bromopiridin-3-karboksilat
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	27848-84-6
ATC kod	C04AE02
PubChem	34040
DrugBank	DB00699
ChemSpider	31373
UNII	JCV8365FWN
KEGG	D01290
Hemijski podaci
Formula	C24H26BrN3O3
Mol. masa	484,386 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1 ; Key: YSEXMKHXIOCEJA-FVFQAYNVSA-N
Farmakokinetički podaci
Bioraspoloživost	<5%
Vezivanje za proteine plazme	>90%
Metabolizam	Ekstenzivni metabolizam prvog prolaza
Poluvreme eliminacije	13–20 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	OTC
Način primene	Oralno, IM, IV

Nicergolin (Sermion) je ergotni derivat koji se koristi za tretiranje senilne demencije i drugih poremećaja vaskularnog porekla. Utvrđeno je da povišava mentalnu agilnost i poboljšava razboritost i percepciju. On snižava vaskularni otpor i povećava arterijski krvni protok u mozgu, poboljšavajući iskorišćenje kiseonika i glukoze u moždanim ćelijama. On ima slična vazoaktivna svojstva u drugim delovima tela, a posebno u plućima.

Nicergolin je registrovan u preko pedeset zemalja, i u upotrebi je duže od tri dekade za tretiranje kognitivnih, afektivnih, i biheviornih poremećaja kod starijih ljudi.^[5]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Fioravanti M, Flicker L (2001). „Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment”. Cochrane Database Syst Rev (4): CD003159. DOI:10.1002/14651858.CD003159. PMID 11687175.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

National Electronic Library for Medicines^{[mrtav link]}

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Fioravanti M, Flicker L (2001). „Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment”. Cochrane Database Syst Rev (4): CD003159. DOI:10.1002/14651858.CD003159. PMID 11687175.

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