Leukocitna elastaza
(Preusmjereno sa stranice Neutrofilna elastaza)
Leukocitna elastaza (EC 3.4.21.37, lizozomalna elastaza, neutrofilna elastaza, polimorfonuklearna leukocitna elastaza, elastaza, elaszim, serinska elastaza, lizozomalna elastaza, granulocitna elastaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Leukocitna elastaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.4.21.37 | ||||||||
| CAS broj | 2594837 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ovaj enzim se razlikuje od pankreasne elastaze po specifičnosti na sintetičim supstratima i po senzitivnosti na inhibitore.
Reference uredi
- ↑ Barrett, A.J. (1981). „Leukocyte elastase”. Methods Enzymol. 80: 581-588. PMID 7043201.
- ↑ Harper, J.W., Cook, R.R., Roberts, C.J., McLaughlin, B.J. and Powers, J.C. (1984). „Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aα, and Staphylococcus aureus' protease V-8 using tripeptide thiobenzyl ester substrates”. Biochemistry 23: 2995-3002. PMID 6380580.
- ↑ Stein, R.L., Strimpler, A.M., Hori, H. and Powers, J.C. (1987). „Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements”. Biochemistry 26: 1301-1305. PMID 3646070.
- ↑ Bode, W., Meyer, E., Jr. and Powers, J.C. (1989). „Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors”. Biochemistry 28: 1951-1963. PMID 2655701.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.