Neurolizin
Neurolizin (EC 3.4.24.16, neurotensinska endopeptidaza, endopeptidaza 24.16, endo-oligopeptidaza B, prolinska-endopeptidaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Neurolizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.16 | ||||||||
| CAS broj | 149371-24-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Preferentno razlaganje u neurotenzinu: Pro10-Tyr
Ovaj enzim deluje i na pojedine peptide, kao što su dinorfini 1-8, koji ne sadrže prolin.
Reference uredi
- ↑ Checler, F., Vincent, J.P. and Kitabgi, P. (1986). „Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes”. J. Biol. Chem. 261: 11274-11281. PMID 3525564.
- ↑ Barelli, H., Vincent, J.-P. and Checler, F. (1988). „Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum”. Eur. J. Biochem. 175: 481-489. PMID 3409880.
- ↑ Checler, F., Barelli, H. and Vincent, J.-P. (1989). „Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies”. Biochem. J. 257: 549-554. PMID 2649078.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.