Nantenin je alkaloid nađen u biljci Nandina domestica[4] kao i u nekim Corydalis vrstama.[5] On je antagonist α1 adrenergičkog receptroa[6] i 5-HT2A serotoninskog receptora,[7] i blokira bihevioralne i fiziološke efekte MDMA kod životinja.[8]
Nantenin
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(IUPAC) ime
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(S)-1,2-Dimetoksi-6-metil-5,6,6a,7-tetrahidro-4H-benzo[de][1,3]benzodioksolo[5,6-g]quinolin
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Klinički podaci
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Identifikatori
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CAS broj
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2565-01-7
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ATC kod
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nije dodeljen
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PubChem[1][2]
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197001
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ChEMBL[3]
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CHEMBL467094 Y
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Hemijski podaci
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Formula
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C20H21NO4
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Mol. masa
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339,385 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C20H21NO4/c1-21-5-4-11-7-17(22-2)20(23-3)19-13-9-16-15(24-10-25-16)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m0/s1 Y Key: WSVWKHTVFGTTKJ-AWEZNQCLSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Shoji N, Umeyama A, Takemoto T, Ohizumi Y (April 1984). „Serotonergic receptor antagonist from Nandina domestica Thunberg”. Journal of Pharmaceutical Sciences 73 (4): 568–70. DOI:10.1002/jps.2600730435. PMID 6726648.
- ↑ Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L (March 1982). „Alkaloids of Corydalis slivenensis”. Planta Medica 44 (3): 168–70. DOI:10.1055/s-2007-971432. PMID 17402105.
- ↑ Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Ohizumi Y (February 2002). „Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity”. European Journal of Pharmacology 437 (3): 173–8. DOI:10.1016/S0014-2999(02)01303-1. PMID 11890906.
- ↑ Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW (May 2009). „(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners”. Bioorganic & Medicinal Chemistry Letters 19 (9): 2530–2. DOI:10.1016/j.bmcl.2009.03.048. PMC 2677726. PMID 19328689.
- ↑ Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH (May 2004). „Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice”. Psychopharmacology 173 (3-4): 270–7. DOI:10.1007/s00213-003-1741-2. PMID 14740148.
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