NAN-190

NAN-190
(IUPAC) ime
	1-(2-Metoksifenil)-4-(4-ftalimidobutil)piperazin
Klinički podaci
Identifikatori
CAS broj	115388-32-4
ATC kod	nije dodeljen
PubChem	4431
ChEMBL	CHEMBL8618
Hemijski podaci
Formula	C23H27N3O3
Mol. masa	393,478 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C23H27N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-5,8-11H,6-7,12-17H2,1H3 ; Key: SJDOMIRMMUGQQK-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

NAN-190 je lek i istraživačka hemikalija koja je u širokoj upotrebi u naučnim istraživanjima. Ranije se smatralo da on deluje kao selektivni antagonist 5-HT_1A receptora, ali su naknadna otkrića pokazala da on isto tako potentno blokira α₂-adrenergički receptor.^[4]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Foong JP, Bornstein JC. (2009). „5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig.”. Neuroreport. 20 (3): 325–330. DOI:10.1097/WNR.0b013e3283232caa. PMID 19190523.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid19190523-4] Foong JP, Bornstein JC. (2009). „5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig.”. Neuroreport. 20 (3): 325–330. DOI:10.1097/WNR.0b013e3283232caa. PMID 19190523.

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