N-acetil-1-D-mio-inozitol-2-amino-2-dezoksi-alfa-D-glukopiranozidna deacetilaza
N-acetil-1-D-mio-inozitol-2-amino-2-dezoksi-alfa-D-glukopiranozidna deacetilaza (EC 3.5.1.103, MshB) je enzim sa sistematskim imenom 1-(2-acetamido-2-dezoksi-alfa-D-glukopiranosil)-1D-mio-inozitol acetilhidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
N-acetil-1-D-mio-inozitol-2-amino-2-dezoksi-alfa-D-glukopiranozidna deacetilaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.5.1.103 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 1-(2-acetamido-2-dezoksi-alfa-D-glukopiranozil)-1D-mio-inozitol + H2O 1-(2-amino-2-dezoksi-alfa-D-glukopiranozid)-1D-mio-inozitol + acetat
Ovaj enzim posreduje reakcioni step koji ograničava brzinu sinteze mikotiola.
Reference uredi
- ↑ Rawat, M., Kovacevic, S., Billman-Jacobe, H. and Av-Gay, Y. (2003). „Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis”. Microbiology 149: 1341-1349. PMID 12724395.
- ↑ Newton, G.L., Av-Gay, Y. and Fahey, R.C. (2000). „N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis”. J. Bacteriol. 182: 6958-6963. PMID 11092856.
- ↑ Maynes, J.T., Garen, C., Cherney, M.M., Newton, G., Arad, D., Av-Gay, Y., Fahey, R.C. and James, M.N. (2003). „The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-α-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold”. J. Biol. Chem. 278: 47166-47170. PMID 12958317.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.