N-(5-amino-5-karboksipentanoil)-L-cisteinil-D-valinska sintaza
N-(5-amino-5-karboksipentanoil)-L-cisteinil-D-valinska sintaza (EC 6.3.2.26, L-delta-(alfa-aminoadipoil)-L-cisteinil-D-valin sintetaza, ACV sintetaza, L-alfa-aminoadipil-cisteinil-valin sintetaza) je enzim sa sistematskim imenom L-2-aminoheksandioat:L-cistein:L-valin ligaza (formira AMP, invertuje valin).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| N-(5-amino-5-karboksipentanoil)-L-cisteinil-D-valinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.26 | ||||||||
| CAS broj | 57219-73-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3 ATP + L-2-aminoheksandioat + L-cistein + L-valin + H2O 3 AMP + 3 difosfat + N-[L-5-amino-5-karboksipentanoil]-L-cisteinil-D-valin
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference uredi
- ↑ Byford, M.F., Baldwin, J.E., Shiau, C.-Y. and Schofield, C.J. (1997). „The mechanism of ACV synthetase”. Chem. Rev. 97: 2631-2649. PMID 11851475.
- ↑ Theilgaard, H.B., Kristiansen, K.N., Henriksen, C.M. and Nielsen, J. (1997). „Purification and characterization of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum”. Biochem. J. 327: 185-191. PMID 9355751.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.