Mikrokokalna nukleaza
Mikrokokalna nukleaza (EC 3.1.31.1, slezinska endonukleaza, termonukleaza, nukleaza T, mikrokokalna endonukleaza, nukleaza T', stafilokokalna nukleaza, slezinska fosfodiesteraza, Staphylococcus aureus nukleaza, Staphylococcus aureus nukleaza B, ribonukleat (dezoksinukleat) 3'-nukleotidohidrolaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Mikrokokalna nukleaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.1.31.1 | ||||||||
| CAS broj | 9013-53-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Endonukleolitičko razlaganje do nukleozid 3'-fosfata i 3'-fosfooligonukleotidnih krajnjih produkata
Ovaj enzim hidrolizuje dvostruke- ili jednostruke supstrate.
Reference uredi
- ↑ Alexander, M., Heppel, L.A. and Hurwitz, J. (1961). „The purification and properties of micrococcal nuclease”. J. Biol. Chem. 236: 3014-3019. PMID 13860347.
- ↑ Anfinsen, C.B., Cuatrecasas, P. and Taniuchi, H. (1971). „Staphylococcal nuclease, chemical properties and catalysis”. u: Boyer, P.D.. The Enzymes. 4 (3rd izd.). New York: Academic Press. str. 177-204.
- ↑ Reddi, K.K. (1967). „Micrococcal nuclease”. Methods Enzymol. 12A: 257-262.
- ↑ Sulkowski, E. and Laskowski, M. (1966). „, Sr. Phosphatase-free crystalline micrococcal nuclease”. J. Biol. Chem. 241: 4386-4388. PMID 5922962.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Anfinsen, C.B., Cuatrecasas, P. and Taniuchi, H. (1971). „Staphylococcal nuclease, chemical properties and catalysis”. u: Boyer, P.D.. The Enzymes. 4 (3rd izd.). New York: Academic Press. str. 177-204.