Metionin transaminaza
Metionin transaminaza (EC 2.6.1.88, metionin-okso-kiselinska transaminaza) je enzim sa sistematskim imenom L-metionin:2-okso-kiselina aminotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Metionin transaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.88 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-metionin + 2-okso karboksilat 2-okso-4-metiltiobutanoat + L-aminokiselina
Ovaj enzim je najaktivniji sa L-metioninom.
Reference uredi
- ↑ Heilbronn, J., Wilson, J. and Berger, B.J. (1999). „Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae”. J. Bacteriol. 181: 1739-1747. PMID 10074065.
- ↑ Dolzan, M., Johansson, K., Roig-Zamboni, V., Campanacci, V., Tegoni, M., Schneider, G. and Cambillau, C. (2004). „Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function”. FEBS Lett. 571: 141-146. PMID 15280032.
- ↑ Schuster, J., Knill, T., Reichelt, M., Gershenzon, J. and Binder, S. (2006). „Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis”. Plant Cell 18: 2664-2679. PMID 17056707.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.