Manitol dehidrogenaza
Manitol dehidrogenaza (EC 1.1.1.255, MTD, NAD+-zavisni manitol dehidrogenaza) je enzim sa sistematskim imenom manitol:NAD+ 1-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Manitol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.255 | ||||||||
| CAS broj | 144941-29-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- D-manitol + NAD+ D-manoza + NADH + H+
Ovaj enzim iz Apium graveolens]] (celera) oksiduje alditole sa minimalnim zahtevom za 2R hiralnost ugljenika susednog primarnom ugljeniku koji podleže oksidaciji. Ovaj enzim je specifičan za NAD+ i ne koristi NADP+.
Reference uredi
- ↑ Stoop, J.M.H. and Pharr, D.M. (1992). „Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots”. Arch. Biochem. Biophys. 298: 612-619. PMID 1416989.
- ↑ Stoop, J.M.H., Williamson, J.D., Conkling, M.A. and Pharr, D.M. (1995). „Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures”. Plant Physiol. (1995) 108: 1219-1225. PMID 7630943.
- ↑ Williamson, J.D., Stoop, J.M.H., Massel, M.O., Conkling, M.A. and Pharr, D.M. (1995). „Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3”. Proc. Natl. Acad. Sci. USA 92: 7148-7152. PMID 7638158.
- ↑ Stoop, J.M.H., Chilton, W.S. and Pharr, D.M. (1996). „Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery”. Phytochemistry 43: 1145-1150.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.