Malat dehidrogenaza (hinon)
Malat dehidrogenaza (hinon) (EC 1.1.5.4, FAD-zavisna malat-vitamin K reduktaza, malat-vitamin K reduktaza, (S)-malat:(akceptor) oksidoreduktaza, L-malat-hinonska oksidoreduktaza, malat:hinon oksidoreduktaza, malat hinonska oksidoreduktaza, MQO, malat:hinon reduktaza, malatna dehidrogenaza (akceptor), FAD-zavisna malatna dehidrogenaza) je enzim sa sistematskim imenom (S)-malat:hinon oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Malat dehidrogenaza (hinon) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.5.4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (S)-malat + hinon oksaloacetat + redukovani hinon
Ovaj enzim je flavoprotein (FAD). Vitamin K i nekoliko drugih hinona mogu da deluju kao akceptori. On se razlikuje od EC 1.1.1.37 (malat dehidrogenaze (NAD+)), EC 1.1.1.82 (malat dehidrogenaza (NADP+)) i EC 1.1.1.299 (malat dehidrogenaza (NAD(P)+)).
Reference uredi
- ↑ Imai, D. and Brodie, A.F. (1973). „A phospholipid-requiring enzyme, malate-vitamin K reductase”. J. Biol. Chem. 248: 7487-7494.
- ↑ Imai, T. (1978). „FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties”. Biochim. Biophys. Acta 523: 37-46. PMID 629992.
- ↑ Reddy, T.L.P., Suryanarayana, P.M. and Venkitasubramanian, T.A. (1975). „Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria”. Biochim. Biophys. Acta 376: 210-218. PMID 234747.
- ↑ Molenaar, D., van der Rest, M.E. and Petrovic, S. (1998). „Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum”. Eur. J. Biochem. 254: 395-403. PMID 9660197.
- ↑ Kather, B., Stingl, K., van der Rest, M.E., Altendorf, K. and Molenaar, D. (2000). „Another unusual type of citric acid cycle enzyme in Helicobacter pylori: the malate:quinone oxidoreductase”. J. Bacteriol. 182: 3204-3209. PMID 10809701.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.