Magnolizin
Magnolizin (EC 3.4.24.62, prooksitocin/neurofizin konvertaza, prooksifizinska proteinaza, prooksitocinska konvertaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Magnolizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.62 | ||||||||
| CAS broj | 162875-09-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza polipeptida sa Arg ili Lys u P1 i P2, e.g. hidroliza prooksitocina u -Lys-Arg-Ala-Val-. Dalja specifičnos je zavisna od organizacije beta-zaokret-alfa-heliksa sa devet ili više ostataka koji sadrže parove baznih aminokiselina blizo centra
Ova endopeptidaza je prisutna u goveđoj hipofizi.
Reference uredi
- ↑ Clamagirand, C., Creminon, C., Fahy, C., Boussetta, H. and Cohen, P. (1987). „Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytosin/neurophysin peptides at the basic amino acid doublet”. Biochemistry 26: 6018-6023. PMID 2825769.
- ↑ Créminon, C., Rholam, M., Boussetta, H., Marrakchi, N. and Cohen, P. (1988). „Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme”. J. Chromatogt. 440: 439-448. PMID 3042797.
- ↑ Brakch, N., Boussetta, H., Rholam, M. and Cohen, P. (1989). „Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model”. J. Biol. Chem. 264: 15912-15916. PMID 2674120.
- ↑ Plevrakis, I, Créminon, C., Clamagirand, C., Brakch, N., Rholam, M. and Cohen, P. (1989). „Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor”. Biochemistry 28: 2705-2710. PMID 2659078.
- ↑ Guillou, M.D., Camier, M. and Clamagirand, C. (1994). „Evidence for the presence of pro-oxytocin/neurophysin converting enzyme in the human ovary”. J. Endocrinol. 142: 345-352. PMID 7931007.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.