Lipid II:glicin gliciltransferaza
Lipid II:glicin gliciltransferaza (EC 2.3.2.16, N-acetilmuramoil-L-alanil-D-glutamil-L-lizil-D-alanil-D-alanin-difosfoundekaprenil-N-acetilglukozamin:N6-glicin transferaza, femX (gen)) je enzim sa sistematskim imenom alanil-D-alanin-difosfo-ditrans,oktacis-undekaprenil-N-acetilglukozamin:glicin N6-gliciltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Lipid II:glicin gliciltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.2.16 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- N-acetilmuramoil-L-alanil-D-izoglutaminil-L-lizil-D-alanil-D-alanin-difosfo-ditrans,oktacis-undekaprenil-N-acetilglukozamin + glicil-tRNK N-acetilmuramoil-L-alanil-D-izoglutaminil-L-lizil-(N6-glicil)-D-alanil-D-alanin-difosfo-ditrans,oktacis-undekaprenil-N-acetilglukozamin + tRNK
Enzim iz Staphylococcus aureus katalizuje transfer glicina sa naelektrisane tRNK na N-acetilmuramoil-L-alanil-D-izoglutaminil-L-lizil-D-alanil-D-alanin-difosfoundekaprenil-N-acetilglukozamin (lipid II), vezujući ga na N6 L-lizina u poziciji 3 pentapeptida.
Reference uredi
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.