Levometamfetamin

Levometamfetamin (l-metamfetamin, levodezoksiefedrin, l-dezoksiefedrin, levmetamfetamin) je levorotarni (R-enantiomer) metamfetamina. Levometamfetamin he simpatomimetički vazokonstriktor koji je aktivni sastojak u pojedinim nazalnim dekongestivima.

Levometamfetamin
(IUPAC) ime
(R)-N-metil-1-fenil-propan-2-amin
Klinički podaci
Identifikatori
CAS broj 537-46-2
ATC kod nije dodeljen
PubChem[1][2] 36604
ChemSpider[3] 33634
UNII 44RAL3456C DaY
KEGG[4] D02291 DaY
Hemijski podaci
Formula C10H15N 
Mol. masa 149,2
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Metabolizam Hepatički
Izlučivanje Renalno
Farmakoinformacioni podaci
Trudnoća ?
Pravni status OTC
Način primene Nazalna inhalacija

Hemija uredi

Levometamfetamin deluje na simpatički nervni sistem i ima malo uticaja na centralni nervni sistem. Smatra se da ne poseduje adikcioni potencijal poput racemskog metamphetamina ili dekstrometamfetamina. Među njegovim fiziološkim dejstvima je vazokonstrikcija što ga čini korisnim za nazalnu dekongestiju.[5] Poluživot eliminacije levometamfetamina je između 13,3 i 15 sati.[6]

Reference uredi

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Nonprescription Products to Avoid With Hypertension by W. Steven Pray, Bernhardt Professor, Nonprescription Products and Devices, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, Oklahoma US Pharm. 2010;35(2):12-15. Posted 2/19/2010. Accessed via internet May 26, 2010. This new article incorporates the information formerly drawn from the article cited at the corresponding point in a previous version of this page, which article's former URL now forms a dead link.
  6. Mendelson J, Uemura N, Harris D, et al. (October 2006). „Human pharmacology of the methamphetamine stereoisomers”. Clin. Pharmacol. Ther. 80 (4): 403–20. DOI:10.1016/j.clpt.2006.06.013. PMID 17015058. 

Spoljašnje veze uredi