Kvercetin 3-O-metiltransferaza
Kvercetin 3-O-metiltransferaza (EC 2.1.1.76, flavonolna 3-O-metiltransferaza, flavonoidna 3-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:3,5,7,3',4'-pentahidroksiflavon 3-O-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kvercetin 3-O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.76 | ||||||||
| CAS broj | 81295-55-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + 3,5,7,3',4'-pentahidroksiflavon S-adenozil-L-homocistein + 3-metoksi-5,7,3',4'-tetrahidroksiflavon
Ovaj enzim je specifičan za kvercetin.
Reference uredi
- ↑ De Luca, V., Brunet, G., Khouri, H., Ibrahim, R. and Hrazdina, G. (1982). „Flavonol 3-O-methyltransferase in plant-tissues”. Z. Naturforsch. 37: 134-135.
- ↑ De Luca, V. and Ibrahim, R.K. (1985). „Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4′-O-methyltransferases”. Arch. Biochem. Biophys. 238: 596-605. PMID 3994393.
- ↑ De Luca, V. and Ibrahim, R.K. (1985). „Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4′-O-methyltransferases”. Arch. Biochem. Biophys. 238: 606-618. PMID 3994394.
- ↑ Ibrahim, R.K. and De Luca, V. (1982). „Polymethylated flavonol synthesis is catalyzed by distinct O-methyltransferases”. Naturwissenschaften 69: 41-42.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.