Katepsin e
Katepsin e (EC 3.4.23.34, proteinaza sporog kretanja, eritrocitna membranska aspartinska proteinaza, SMP, eritrocitna membranska aspartinska proteinaza, EMAP, nepepsinska proteinaza, katepsin D-slična kiselinska proteinaza, katepsinska E-slična kiselinska proteinaza, katepsinska D-tip proteinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Katepsin e | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.23.34 | ||||||||
| CAS broj | 110910-42-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Aktivnost slična katepsinu D, sa malo širom specifičnošću
Ovaj enzim je prisutan u stomaku želucu, slezini i eritrocitnim membranama.
Reference uredi
- ↑ Lapresle, C., Puizdar, V., Porchon-Bertolotto, C., Joukoff, E. and Turk, V. (1986). „Structural differences between rabbit cathepsin E and cathepsin D”. Biol. Chem. Hoppe-Seyler 367: 523-526. PMID 3741628.
- ↑ Yonezawa, S., Fujii, K., Maejima, Y., Tamoto, K., Mori, Y. and Muto, N. (1988). „Further studies on rat cathepsin E: subcellular localization and existence of the active subunit form”. Arch. Biochem. Biophys. 267: 176-183. PMID 3058036.
- ↑ Jupp, R.A., Richards, A.D., Kay, J., Dunn, B.M., Wyckoff, J.B., Samloff, I.M. and Yamamoto, K. (1988). „Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E”. Biochem. J. 254: 895-898. PMID 3058118.
- ↑ Azuma, T., Pals, G., Mohandas, T.K., Couvreur, J.M. and Taggart, R.T. (1989). „Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases”. J. Biol. Chem. 264: 16748-16753. PMID 2674141.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.