Karnitin palmitoiltransferaza I
Karnitinska palmitoiltransferaza I (CPT1, Karnitinska palmitoiltransferaza I, CAT1) mitohondrijski je enzim.[1][2] Ona pripada familiji enzima koji se nazivaju karnitinske aciltransferaze.[3] Sledeće CPT1 izoforme su poznate: CPT1A, CPT1B, i CPT1C. CPT1 je vezana za spoljašnju mitohondrijsku membranu i posreduje transport dugolančanih masnih kiselina kroz membranu putem njihovog vezivanja za karnitin. Ova enzim se može inhibirati dejstvom malonil KoA. Njegova uloga u metabolizmu masnih kiselina ga čini značajnim za mnoge metaboličke poremećaje, npr. dijabetes. Njegova kristalna struktura nije poznata, te detaljan mehanizam njegovog dejstva nije utvrđen.
| Karnitinska palmitoiltransferaza 1A (jetra) | |
|---|---|
| Identifikatori | |
| Simbol | CPT1A |
| Alt. simboli | CPT1 |
| Entrez | 1374 |
| Hugo | 2328 |
| OMIM | 600528 |
| RefSek | NM_001876 |
| UniProt | P50416 |
| Drugi podaci | |
| EC broj | 2.3.1.21 |
| Lokus | Hrom. 11 q13.1-13.5 |
| Karnitinska palmitoiltransferaza 1B (mišići) | |
|---|---|
| Identifikatori | |
| Simbol | CPT1B |
| Entrez | 1375 |
| Hugo | 2329 |
| OMIM | 601987 |
| RefSek | NM_152245 |
| UniProt | Q92523 |
| Drugi podaci | |
| Lokus | Hrom. 22 q13.3 |
| Karnitinska palmitoiltransferaza 1C (mozak) | |
|---|---|
| Identifikatori | |
| Simbol | CPT1C |
| Entrez | 126129 |
| Hugo | 18540 |
| OMIM | 608846 |
| RefSek | NM_152359 |
| UniProt | Q8TCG5 |
| Drugi podaci | |
| Lokus | Hrom. 19 q13.33 |
Reference uredi
- ↑ van der Leij FR, Huijkman NC, Boomsma C, Kuipers JR, Bartelds B (2000). „Genomics of the human carnitine acyltransferase genes”. Mol. Genet. Metab. 71 (1–2): 139–53. DOI:10.1006/mgme.2000.3055. PMID 11001805.
- ↑ Bonnefont JP, Djouadi F, Prip-Buus C, Gobin S, Munnich A, Bastin J (2004). „Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects”. Mol. Aspects Med. 25 (5–6): 495–520. DOI:10.1016/j.mam.2004.06.004. PMID 15363638.
- ↑ Tong L, Gerwald J (2003). „Crystal Structure of Carnitine Acetyltransferase and Implications for the Catalytic Mechanism and Fatty Acid Transport”. Cell 112 (1): 113–122. DOI:10.1016/S0092-8674(02)01228-X. PMID 12526798.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.