Karboksipeptidaza u
Karboksipeptidaza u (EC 3.4.17.20, argininska karboksipeptidaza, karboksipeptidaza R, plazmatična karboksipeptidaza B, trombinom aktivirani fibrinolizni inhibitor) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Karboksipeptidaza u | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.17.20 | ||||||||
| CAS broj | 156621-18-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Odvajanje C-terminalnog Arg i Lys sa polipeptida
Pro-karboksipeptidaza U se u (ljudskoj) plazmi aktivira trombinom ili plazminom tokom zgrušavanja, čime se formira nestabilna karboksipeptidaza U.
Reference uredi
- ↑ Eaton, D.L., Malloy, B.E., Tsai, S.P., Henzel, W. and Drayna, D. (1991). „Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma”. J. Biol. Chem. 266: 21833-21838. PMID 1939207.
- ↑ Shinohara, T., Sakurada, C., Suzuki, T., Takeuchi, O., Campbell, W., Ikeda, S., Okada, N. and Okada, H. (1994). „Pro-carboxypeptidase R cleaves bradykinin following activation”. Int. Arch. Allergy Immunol. 103: 400-404. PMID 8130654.
- ↑ Wang, W., Hendriks, D.F. and Scharpé, S. (1994). „Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen”. J. Biol. Chem. 269: 15937-15944. PMID 8195249.
- ↑ Tan, A.K. and Eaton, D.L. (1995). „Activation and characterization of procarboxypeptidase B from human plasma”. Biochemistry 34: 5811-5816. PMID 7727441.
- ↑ Broze, G.J., Jr. and Higuchi, D.A. (1996). „Coagulation-dependent inhibition of fibrinolysis: Role of carboxypeptidase U and the premature lysis of clots from hemophilic plasma”. Blood 88: 3815-3823. PMID 8916945.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.