Kanabigerol
Kanabigerol (CBG) je kanabinoid iz Cannabis roda biljki koji nije psihoaktivan. Kanabigerol je prisutan u visokim koncentracijama u industrijskoj konoplji.
(IUPAC) ime | |||
---|---|---|---|
2-[(2E)-3,7-dimetilokta-2,6-dienil]-5-pentil-benzen-1,3-diol | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 25654-31-3 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 5315659 | ||
ChemSpider[3] | 4474921 | ||
ChEMBL[4] | CHEMBL497318 | ||
Hemijski podaci | |||
Formula | C21H32O2 | ||
Mol. masa | 316,48 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Kanabigerol deluje sa visokim afinitetom kao agonist α2-adrenergičkog receptora, umereni antagonist 5-HT1A receptora, i slab antagonist CB1 receptora.[5] It also binds to the CB2 receptor, but whether it acts as an agonist or antagonist at this site is unknown.[5]
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ 5,0 5,1 Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee R (December 2009). „Evidence that the plant cannabinoid cannabigerol is a highly potent alpha(2)-adrenoceptor agonist and moderately potent 5HT receptor antagonist”. British Journal of Pharmacology 159 (1): 129–141. DOI:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104.