Kalpain-3
Kalpain-3 (EC 3.4.22.54, p94, kalpain p94, CAPN3, mišićni kalpain, kalpain 3, kalcijumom aktivirana neutralna proteinaza 3, mišićno specifična kalcijumom aktivirana neutralna proteaza 3, CANP 3, kalpain L3) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kalpain-3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.54 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Endopeptidazazno dejstvo sa širokom specifičnošću
Ovaj od Ca2+ zavistan enzim je prisutan u skeletalnim mišićima.
Reference uredi
- ↑ Sorimachi, H., Imajoh-Ohmi, S., Emori, Y., Kawasaki, H., Ohno, S., Minami, Y. and Suzuki, K. (1989). „Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and μ-types. Specific expression of the mRNA in skeletal muscle”. J. Biol. Chem. 264: 20106-20111. PMID 2555341.
- ↑ Sorimachi, H., Kinbara, K., Kimura, S., Takahashi, M., Ishiura, S., Sasagawa, N., Sorimachi, N., Shimada, H., Tagawa, K., Maruyama, K. and Suzuki, K. (1995). „Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence”. J. Biol. Chem. 270: 31158-31162. PMID 8537379.
- ↑ Rey, M.A. and Davies, P.L. (2002). „The protease core of the muscle-specific calpain, p94, undergoes Ca2+-dependent intramolecular autolysis”. FEBS Lett. 532: 401-406. PMID 12482600.
- ↑ García Díaz, B.E., Gauthier, S. and Davies, P.L. (2006). „Ca2+ dependency of calpain 3 (p94) activation”. Biochemistry 45: 3714-3722. PMID 16533054.
- ↑ Ono, Y., Torii, F., Ojima, K., Doi, N., Yoshioka, K., Kawabata, Y., Labeit, D., Labeit, S., Suzuki, K., Abe, K., Maeda, T. and Sorimachi, H. (2006). „Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system”. J. Biol. Chem. 281: 18519-18531. PMID 16627476.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.