Kalcifediol

Kalcifediol
	(6R)-6-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(5S)-5-; Hidroksi-2-metiliden-cikloheksiliden]; etiliden]-7a-metil-2,3,3a,5,6,7-heksahidro-; 1H-inden-1-il]-2-metil-heptan-2-ol
Drugi nazivi	25-Hidroksivitamin D3; 25-Hidroksiholekalciferol
Identifikacija
CAS registarski broj	19356-17-3
PubChem	5283731
ChemSpider	4446820
UNII	T0WXW8F54E
DrugBank	DB00146
MeSH	Calcifediol
ChEMBL	CHEMBL1222
ATC code	A11CC06
Jmol-3D slike	Slika 1
SMILES
	O[C@@H]1CC(\C(=C)CC1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CCCC(O)(C)C)C
InChI
	InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 ; Kod: JWUBBDSIWDLEOM-DTOXIADCSA-N InChI=1/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1; Kod: JWUBBDSIWDLEOM-DTOXIADCBI
Svojstva
Molekulska formula	C27H44O2
Molarna masa	400,64 g/mol
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Kalcifediol (kalcidiol, 25-hidroksiholekalciferol, 25-hidroksivitamin D, 25(OH)D),^[5] je prehormon koji se formira u jetri putem hidroksilacije vitamina D₃ (holekalciferola) posredstvom enzima holekalciferol 25-hidroksilaza. Koncentracija ovog molekula se meri radi određivanja pacijentovog statusa vitamina D.^[6] Kalcifediol se zatim konvertuje u bubrezima (enzimom 25(OH)D-1α-hidroksilaza) u kalcitriol (1,25-(OH)₂D₃), sekosteroidni hormon koji je aktivna forma vitamina D. On se takođe može konvertovati u 24-hidroksikalcidiol u bubrezima putem 24-hidroksilacije.^[7]^[8]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ "Nomenclature of Vitamin D. Recommendations 1981. IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN)" reproduced at the Queen Mary, University of London website., Pristupljeno 21. 3. 2010.
↑ Holick, MF; Deluca, HF; Avioli, LV (1972). „Isolation and identification of 25-hydroxycholecalciferol from human plasma”. Archives of Internal Medicine 129 (1): 56–61. DOI:10.1001/archinte.1972.00320010060005. PMID 4332591.
↑ Bender, David A.; Mayes, Peter A (2006). „Micronutrients: Vitamins & Minerals”. u: Victor W. Rodwell; Murray, Robert F.; Harper, Harold W.; Granner, Darryl K.; Mayes, Peter A.. Harper's Illustrated Biochemistry. New York: Lange/McGraw-Hill. str. 492–3. ISBN 0-07-146197-3. , Pristupljeno 10. 12. 2008. through Google Book Search.
↑ Institute of Medicine (1997). „Vitamin D”. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, D.C: National Academy Press. str. 254. ISBN 0-309-06403-1.

Literatura uredi

Bender, David A.; Mayes, Peter A (2006). „Micronutrients: Vitamins & Minerals”. u: Victor W. Rodwell; Murray, Robert F.; Harper, Harold W.; Granner, Darryl K.; Mayes, Peter A.. Harper's Illustrated Biochemistry. New York: Lange/McGraw-Hill. str. 492–3. ISBN 0-07-146197-3.
Institute of Medicine (1997). „Vitamin D”. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, D.C: National Academy Press. str. 254. ISBN 0-309-06403-1.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] "Nomenclature of Vitamin D. Recommendations 1981. IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN)" reproduced at the Queen Mary, University of London website., Pristupljeno 21. 3. 2010.

[6] Holick, MF; Deluca, HF; Avioli, LV (1972). „Isolation and identification of 25-hydroxycholecalciferol from human plasma”. Archives of Internal Medicine 129 (1): 56–61. DOI:10.1001/archinte.1972.00320010060005. PMID 4332591.

[7] Bender, David A.; Mayes, Peter A (2006). „Micronutrients: Vitamins & Minerals”. u: Victor W. Rodwell; Murray, Robert F.; Harper, Harold W.; Granner, Darryl K.; Mayes, Peter A.. Harper's Illustrated Biochemistry. New York: Lange/McGraw-Hill. str. 492–3. ISBN 0-07-146197-3. , Pristupljeno 10. 12. 2008. through Google Book Search.

[8] Institute of Medicine (1997). „Vitamin D”. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, D.C: National Academy Press. str. 254. ISBN 0-309-06403-1.

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