JTE-907 je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni inverzni agonist CB2 receptora.[3][4] On ima antiinflamatorno dejstvo u životinjskim studijama.[5] Smatra se da posreduje interakciju između CB2 receptora u IgE.[6]
JTE-907
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(IUPAC) ime
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N-(benzo[1,3]dioksol-5-ilmetil)-7-metoksi-2-okso-8-pentiloksi-1,2-dihidrohinolin-3-karboksamid
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Klinički podaci
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Identifikatori
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CAS broj
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282089-49-0
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ATC kod
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nije dodeljen
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PubChem[1][2]
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9867770
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Hemijski podaci
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Formula
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C24H26N2O6
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Mol. masa
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438,472
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C24H26N2O6/c1-3-4-5-10-30-22-19(29-2)9-7-16-12-17(24(28)26-21(16)22)23(27)25-13-15-6-8-18-20(11-15)32-14-31-18/h6-9,11-12H,3-5,10,13-14H2,1-2H3,(H,25,27)(H,26,28) Y Key: GRAJFFFXJYFVOC-UHFFFAOYSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T (2001). „In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor”. The Journal of Pharmacology and Experimental Therapeutics 296 (2): 420–5. PMID 11160626.
- ↑ Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T (2006). „Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists”. Journal of Medical Chemistry 49 (6): 2022–7. DOI:10.1021/jm050879z. PMID 16539390.
- ↑ Ueda Y, Miyagawa N, Matsui T, Kaya T, Iwamura H (2005). „Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice”. European Journal of Pharmacology 520 (1–3): 164–71. DOI:10.1016/j.ejphar.2005.08.013. PMID 16153638.
- ↑ Ueda Y, Miyagawa N, Wakitani K (2007). „Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice”. Life Sciences 80 (5): 414–9. DOI:10.1016/j.lfs.2006.09.026. PMID 17055000.
Spoljašnje veze
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