Izopenicilin-N sintaza
Izopenicilin-N sintaza (EC 1.21.3.1, izopenicilin N sintetaza) je enzim sa sistematskim imenom N-((5S)-5-amino-5-karboksipentanoil)-L-cisteinil-D-valin:kiseonik oksidoreduktaza (ciklizacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Izopenicilin-N sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.21.3.1 | ||||||||
| CAS broj | 78642-31-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- N-[(5S)-5-amino-5-karboksipentanoil]-L-cisteinil-D-valin + O2 izopenicilin N + 2 H2O
Ovaj enzim učestvuje u biosintezi penicilina.
Reference uredi
- ↑ Huffman, G.W., Gesellchen, P.D., Turner, J.R., Rothenberger, R.B., Osborne, H.E., Miller, F.D., Chapman, J.L. and Queener, S.W. (1992). „Substrate specificity of isopenicillin N synthase”. J. Med. Chem. 35: 1897-1914. PMID 1588566.
- ↑ Roach, P.L., Clifton, I.J., Fulop, V., Harlos, K., Barton, G.J., Hajdu, J., Andersson, I., Schofield, C.J. and Baldwin, J.E. (1995). „Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes”. Nature 375: 700-704. PMID 7791906.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.