Izocitratna lijaza
Izocitratna lijaza (EC 4.1.3.1, izocitraza, izocitritaza, izocitrataza, treo-Ds-izocitrat glioksilat-lijaza, izocitrat glioksilat-lijaza) je enzim sa sistematskim imenom izocitrat glioksilat-lijaza (formira sukcinat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Izocitratna lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 4.1.3.1 | ||||||||
| CAS broj | 9045-78-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- izocitrat sukcinat + glioksilat
Izomer izocitrata koji učestvuje u ovoj reakciji je (1R,2S)-1-hidroksipropan-1,2,3-trikarboksilat.
Reference uredi
- ↑ McFadden, B.A. and Howes, W.V. (1963). „Crystallisation and some properties of isocitrate lyase from Pseudomonas indigofera”. J. Biol. Chem. 238: 1737-1742.
- ↑ Shiio, I., Shiio, T. and McFadden, B.A. (1965). „Isocitrate lyase from Pseudomonas indigofera. I. Preparation, amino acid composition and molecular weight”. Biochim. Biophys. Acta 96: 114-122. PMID 14285253.
- ↑ Vickery, H.B. (1962). „A suggested new nomenclature for the isomers of isocitric acid”. J. Biol. Chem. 237: 1739-1741. PMID 13925783.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.