Inhibitor aromatične L-aminokiselinske dekarboksilaze
Inhibotor aromatične L-aminokiselinske dekarboksilaze (Inhibitor DOPA dekarboksilaze, DDCI, AAADI) lek je koji inhibira sintezu dopamina posredstvom enzima aromatična-L-aminokiselinska dekarboksilaza (AAAD, DOPA dekarboksilaza, DDC).
Indikacije uredi
Periferni DDCI ne prolaze kroz krvno-moždanu barijeru (BBB) i koriste se zajedno sa L-DOPA (Levodopa) u tretmanu Parkinsonove bolesti (PD). Oni blokiraju perifernu konverziju L-DOPA molekula u dopamin, radi redukovanja nepoželjnih nuspojava.[1][2][3]
Reference uredi
- ↑ „Editorial: Dopa decarboxylase inhibitors”. British Medical Journal 4 (5939): 250–1. November 1974. DOI:10.1136/bmj.4.5939.250. PMC 1612227. PMID 4425849.
- ↑ Cotzias, G. C., Papavasiliou, P. S., and Gellene, R., New England Journalof Medicine, 1969, 280, 337.
- ↑ Yahr, M. D., in Advances in Neurology, ed. M. D. Yahr, p. vi, vol. 2. New York, Raven Press, 1973.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.