Pukatein
(Preusmjereno sa stranice IKMXUUHNYQWZBC-GFCCVEGCSA-N)
Pukatein je alkaloid koji je prisutan u kori novozelandskog drveta Laurelia novae-zelandiae ("Pukatea"). Ekstrakt kore se koristi kao tradicionalni maorski biljni lek koji deluje kao analgetik.[4][5] Smatra se da je pukatein aktivna komponenta,[6] jer je sličan po strukturi i aktivnosti sa alkaloidima poput glaucina i tetrahidropalmatina koji su prisutni u kineskim medicinskim biljkama sa analgetskom primenom. Pukatein ima višestruke mehanizme dejstva, pri čemu su najprominentnija njegova dejstva kao agonist D2 dopaminskog receptora i antagonist α1 adrenergičkog receptora.[7][8]
(IUPAC) ime | |||
---|---|---|---|
(7aR)-7-metil-6,7,7a,8-tetrahidro-5H-benzo[g][1,3]benzodioksolo[6,5,4-de]hinolin-12-ol | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 81-67-4 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 442340 | ||
ChEMBL[3] | CHEMBL258370 | ||
Hemijski podaci | |||
Formula | C18H17NO3 | ||
Mol. masa | 295,332 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Sinonimi | (R)-11-hydroxy-1,2-methylenedioxyaporphine | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Pukatea. Te Ara: The Encyclopedia of New Zealand
- ↑ Pukatea. University of Otago Pharmacy Dept.
- ↑ Fogg WS. The Pharmacological Action of Pukateine. Journal of Pharmacology And Experimental Therapeutics. 1935 Jun;54(2):167-187.
- ↑ Dajas-Bailador FA, Asencio M, Bonilla C, Scorza MC, Echeverry C, Reyes-Parada M, Silveira R, Protais P, Russell G, Cassels BK, Dajas F. Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission. General Pharmacology. 1999 Mar;32(3):373-9. PMID 10211594
- ↑ Valiente M, D'Ocon P, Noguera MA, Cassels BK, Lugnier C, Ivorra MD. Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes. Planta Medica. 2004 Jul;70(7):603-9. PMID 15254852