Hitin disaharidna deacetilaza
Hitin disaharidna deacetilaza (EC 3.5.1.105, hitobioza amidohidolaza, COD, hitin oligosaharidna deacetilaza, hitin oligosaharidna amidohidolaza) je enzim sa sistematskim imenom 2-(acetilamino)-4-O-(2-(acetilamino)-2-dezoksi-beta-D-glukopiranosil)-2-dezoksi-D-glukopiranoza acetilhidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hitin disaharidna deacetilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.105 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2-(acetilamino)-4-O-[2-(acetilamino)-2-dezoksi-beta-D-glukopiranozil]-2-dezoksi-beta-D-glukopiranoza + H2O 2-(acetilamino)-4-O-(2-amino-2-dezoksi-beta-D-glukopiranozil)-2-dezoksi-beta-D-glukopiranoza + acetat
Ovaj enzim učestvuje u kataboličkoj kaskadi hitinolutičkih Vibrio vrsta.
Reference uredi
- ↑ Kadokura, K., Rokutani, A., Yamamoto, M., Ikegami, T., Sugita, H., Itoi, S., Hakamata, W., Oku, T. and Nishio, T. (2007). „Purification and characterization of Vibrio parahaemolyticus extracellular chitinase and chitin oligosaccharide deacetylase involved in the production of heterodisaccharide from chitin”. Appl. Microbiol. Biotechnol. 75: 357-365. PMID 17334758.
- ↑ Hirano, T., Kadokura, K., Ikegami, T., Shigeta, Y., Kumaki, Y., Hakamata, W., Oku, T. and Nishio, T. (2009). „Heterodisaccharide 4-O-(N-acetyl-β-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes”. Glycobiology 19: 1046-1053. PMID 19553519.
- ↑ Ohishi, K., Yamagishi, M., Ohta, T., Motosugi, M., Izumida, H., Sano, H., Adachi, K., Miwa, T. (1997). „Purification and properties of two deacetylases produced by Vibrio alginolyticus H-8”. Biosci. Biotechnol. Biochem. 61: 1113-1117.
- ↑ Ohishi, K., Murase, K., Ohta, T. and Etoh, H. (2000). „Cloning and sequencing of the deacetylase gene from Vibrio alginolyticus H-8”. J. Biosci. Bioeng. 90: 561-563. PMID 16232910.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.