Histolizain
Histolizain (EC 3.4.22.35, histolizin, histolizin, Entamoeba histolytica cisteinska proteinaza, amebapain, Entamoeba histolytica cisteinska proteaza, Entamoeba histolytica neutralna tiolna proteinaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Histolizain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.35 | ||||||||
| CAS broj | 92228-52-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza proteina, uključujući membranski kolagen i azokasein. Preferentno razlaganje: Arg-Arg- u malim molekulima uključujući Z-Arg-Arg-NHMec
Ovaj enzim je prisutan u protozoi, Entamoeba histolytica.
Reference uredi
- ↑ Lushbaugh, W.B., Hofbauer, A.F. and Pittman, F.E. (1985). „Entamoeba histolytica: purification of cathepsin B”. Exp. Parasitol. 59: 328-336. PMID 2860002.
- ↑ Luaces, A.L. and Barrett, A.J. (1988). „Affinity purification and biochemical characterization of histolysin: the major cysteine proteinase of Entamoeba histolytica”. Biochem. J. 250: 903-909. PMID 2898937.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.