Hidroksilamin dehidrogenaza
Hidroksilamin dehidrogenaza (EC 1.7.2.6, HAO (nespecifična), hidroksilamin oksidoreduktaza (nespecifična)) je enzim sa sistematskim imenom hidroksilamin:fericitohrom-c oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hidroksilamin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.7.2.6 | ||||||||
| CAS broj | 9075-43-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) hidroksilamin + H2O + 2 fericitohrom c nitrit + 2 ferocitohrom c + 5 H+
- (2) hidroksilamin + fericitohrom c azot oksid + ferocitohrom c + 3 H+
Enzimi iz nitrifikujućih bakterija Nitrosomonas europaea i metilotrofnih bakterija Metilococcus capsulatus su hemoproteini sa sedam c-tip hemova i jednim specijalizovanim P-460-tipom hema po podjedinici.
Reference uredi
- ↑ Rees, M. (1968). „Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I. Purification of hydroxylamine oxidase”. Biochemistry 7: 353-366. PMID 5758552.
- ↑ Hooper, A.B. and Terry, K.R. (1979). „Hydroxylamine oxidoreductase of Nitrosomonas. Production of nitric oxide from hydroxylamine”. Biochim. Biophys. Acta 571: 12-20. PMID 497235.
- ↑ Hooper, A.B. and Balny, C. (1982). „Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics”. FEBS Lett. 144: 299-303. PMID 7117545.
- ↑ Lipscomb, J.D. and Hooper, A.B. (1982). „Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy”. Biochemistry 21: 3965-3972. PMID 6289867.
- ↑ Poret-Peterson, A.T., Graham, J.E., Gulledge, J. and Klotz, M.G. (2008). „Transcription of nitrification genes by the methane-oxidizing bacterium, Methylococcus capsulatus strain Bath”. ISME J. 2: 1213-1220. PMID 18650926.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.