Glukuronozil-N-acetilglukozaminil-proteoglikan 4-a-N-acetilglukozaminiltransferaza
Glukuronozil-N-acetilglukozaminil-proteoglikan 4-a-N-acetilglukozaminiltransferaza (EC 2.4.1.224, alfa-N-acetilglukozaminiltransferaza II glukuronil-N-acetilglukozaminilproteoglikan alfa-1,4-N-acetilglukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:beta-D-glukuronazil-(1->4)-N-acetil-alfa-D-glukozaminil-proteoglikan 4-alfa-N-acetilglukozaminiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glukuronozil-N-acetilglukozaminil-proteoglikan 4-a-N-acetilglukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.224 | ||||||||
| CAS broj | 336193-98-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- UDP-N-acetil-D-glukozamin + beta-D-glukuronazil-(1->4)-N-acetil-alfa-D-glukozaminil-proteoglikan UDP + N-acetil-alfa-D-glukozaminil-(1->4)-beta-D-glukuronazil-(1->4)-N-acetil-alfa-D-glukozaminil-proteoglikan
Ovaj enzim učestvuje u inicijaciji sinteze heparina i heparan sulfata.
Reference uredi
- ↑ Kim, B.T., Kitagawa, H., Tamura, J., Saito, T., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. (2001). „Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode α1,4-N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/heparin biosynthesis”. Proc. Natl. Acad. Sci. USA 98: 7176-7181. PMID 11390981.
- ↑ Kitagawa, H., Egusa, N., Tamura, J.I., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. (2001). „rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel α1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate”. J. Biol. Chem. 276: 4834-4838. PMID 11121397.
- ↑ Senay, C., Lind, T., Muguruma, K., Tone, Y., Kitagawa, H., Sugahara, K., Lidholt, K., Lindahl, U. and Kusche-Gullberg, M. (2000). „The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis”. EMBO Rep. 1: 282-286. PMID 11256613.
- ↑ Lind, T., Tufaro, F., McCormick, C., Lindahl, U. and Lidholt, K. (1998). „The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate”. J. Biol. Chem. 273: 26265-26268. PMID 9756849.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.