Glukoza-1-fosfat timidililtransferaza
Glukoza-1-fosfat timidililtransferaza (EC 2.7.7.24, glukoza 1-fosfat timidililtransferaza, dTDP-glukoza sintaza, dTDP-glukoza pirofosforilaza, timidin difosfoglukoza pirofosforilaza, timidin difosfat glukoza pirofosforilaza, TDP-glukoza pirofosforilaza) je enzim sa sistematskim imenom dTTP:alfa-D-glukoza-1-fosfat thimidililtransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glukoza-1-fosfat timidililtransferaza | |||||||||
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| Glukoza-1-fosfat timidililtransferaza tetramer, E.Coli | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.7.24 | ||||||||
| CAS broj | 2602781 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- dTTP + alfa-D-glukoza 1-fosfat difosfat + dTDP-alfa-D-glukoza
Ovaj enzim učestvuje u biosinteza L-ramnoze kod bakterija.
Reference uredi
- ↑ Kornfeld, S. and Glaser, L. (1961). „The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose”. J. Biol. Chem. 236: 1791-1794. PMID 13753209.
- ↑ Pazur, J.H. and Shuey, E.W. (1961). „The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose”. J. Biol. Chem. 236: 1780-1785. PMID 13733719.
- ↑ Zuccotti, S., Zanardi, D., Rosano, C., Sturla, L., Tonetti, M. and Bolognesi, M. (2001). „Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase”. J. Mol. Biol. 313: 831-843. PMID 11697907.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.