Glikoprotein-N-acetilgalaktozamin 3-b-galaktoziltransferaza
Glikoprotein-N-acetilgalaktozamin 3-b-galaktoziltransferaza (EC 2.4.1.122, uridin difosfogalaktoza-mucin beta-(1->3)-galaktoziltransferaza, UDP-galaktoza:glikoprotein-N-acetil-D-galaktozamin 3-beta-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:glikoprotein-N-acetil-D-galaktozamin 3-beta-D-galaktoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glikoprotein-N-acetilgalaktozamin 3-b-galaktoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.122 | ||||||||
| CAS broj | 97089-61-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-alfa-D-galaktoza + glikoprotein N-acetil-D-galaktozamin UDP + glikoprotein D-galaktozil-(1->3)-N-acetil-D-galaktozamin
Neredukujući za O-serin-vezani N-acetilgalaktozaminski ostaci mucinskih glikoproteina mogu da budu akceptori.
Reference uredi
- ↑ Hesford, F.J., Berger, E.G. and van den Eijnden, D.H. (1981). „Identification of the product formed by human erythrocyte galactosyltransferase”. Biochim. Biophys. Acta 659: 302-311. PMID 6789880.
- ↑ Mendicino, J., Sivakami, S., Davila, M. and Chandrasekaran, E.V. (1982). „Purification and properties of UDP-gal:N-acetylgalactosaminide mucin: β1,3-galactosyltransferase from swine trachea mucosa”. J. Biol. Chem. 257: 3987-3994. PMID 6801057.
- ↑ Schachter, H., Narasimhan, S., Gleeson, P. and Vella, G. (1983). „Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type”. Methods Enzymol. 98: 98-134. PMID 6366476.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.