Geosminska sintaza
Geosminska sintaza (EC 4.1.99.16) je enzim sa sistematskim imenom germakradienol geosmin-lijaza (formira aceton).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Geosminska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 4.1.99.16 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1E,4S,5E,7R)-germakra-1(10),5-dien-11-ol + H2O (-)-geosmin + aceton
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference uredi
- ↑ Jiang, J., He, X. and Cane, D.E. (2006). „Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin”. J. Am. Chem. Soc. 128: 8128-8129. PMID 16787064.
- ↑ Cane, D.E., He, X., Kobayashi, S., Omura, S. and Ikeda, H. (2006). „Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase”. J. Antibiot. (Tokyo) 59: 471-479. PMID 17080683.
- ↑ Jiang, J., He, X. and Cane, D.E. (2007). „Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme”. Nat. Chem. Biol. 3: 711-715. PMID 17873868.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.