Furin
Furin (EC 3.4.21.75, prohormonska konvertaza, PACE, enzim razlaganja uparenih baznih aminokiselina, konvertujući enzim uparenih baznih aminokiselina, serinska proteinaza PACE, PC1, SPC3, proproteinska konvertaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Furin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.21.75 | ||||||||
| CAS broj | 141760-45-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Oslobađanje maturisanih proteina iz njihovih proproteina razlaganjem -Arg-Xaa-Yaa-Arg- veza, gde Xaa može da bude bilo koja aminokiselina, dok je Yaa: Arg ili Lys. Oslobađa se albumin, komplementna komponenta C3 i von Vilebrandov faktor iz njihovih prekursora
Ova grupa peptidaza je strukturno i funkcionalno slična sa keksinom.
Reference uredi
- ↑ Van de Ven, W.J.M., Voorberg, J., Fontijn, R., Pannekoek, H., van den Ouweland, A.M.W., van Duijnhoven, H.L.P., Roebroek, A.J.M. and Siezen, R.J. (1990). „Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes”. Mol. Biol. Rep. 14: 265-275. PMID 2094803.
- ↑ Van de Ven, W.J.M., Creemers, J.W.M. and Roebroek, A.J.M. (1991). „Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway”. Enzyme 45: 257-270. PMID 1843280.
- ↑ Hatsuzawa, K., Murakami, K. and Nakayama, K. (1992). „Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites”. J. Biochem. (Tokyo) 111: 296-301. PMID 1587790.
- ↑ Seidah, N.G. and Chrétien, M. (1992). „Proprotein and prohormone convertases of the subtilisin family: recent developments and future perspectives”. Trends Endocrinol. Metab. 3: 133-140.
- ↑ Steiner, D.F., Smeekens, S.P., Ohagi, S. and Chan, S.J. (1992). „The new enzymology of precursor processing endoproteases”. J. Biol. Chem. 267: 23435-23438. PMID 1429684.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.