Fumarat reduktaza (menahinon)
Fumarat reduktaza (menahinon) (EC 1.3.5.4, FRD, menahinol-fumaratna oksidoreduktaza, sukcinatna dehidrogenaza (menahinon)) je enzim sa sistematskim imenom sukcinat:menahinon oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fumarat reduktaza (menahinon) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.5.4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ova reakcija je katalizovana u reverznom smeru. Enzim je deo anaerobnog lanca elektronskog transfera pojedinih bakterija. On omogućava fumaratu da služi kao terminalni elektronski akceptor.
Reference uredi
- ↑ Iverson, T.M., Luna-Chavez, C., Cecchini, G. and Rees, D.C. (1999). „Structure of the Escherichia coli fumarate reductase respiratory complex”. Science 284: 1961-1966. PMID 10373108.
- ↑ Cecchini, G., Schroder, I., Gunsalus, R.P. and Maklashina, E. (2002). „Succinate dehydrogenase and fumarate reductase from Escherichia coli”. Biochim. Biophys. Acta 1553: 140-157. PMID 11803023.
- ↑ Iverson, T.M., Luna-Chavez, C., Croal, L.R., Cecchini, G. and Rees, D.C. (2002). „Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site”. J. Biol. Chem. 277: 16124-16130. PMID 11850430.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.