Fosfatidilinozitolna diacilglicerol-lijaza
Fosfatidilinozitolna diacilglicerol-lijaza (EC 4.6.1.13, monofosfatidilinozitol fosfodiesteraza, fosfatidilinozitol fosfolipaza C, 1-fosfatidilinozitol fosfodiesteraza, 1-fosfatidil-D-mio-inozitol inozitolfosfohidrolaza (formira ciklična-fosfat), 1-fosfatidil-1D-mio-inozitol diacilglicerol-lijaza (formira 1,2-ciklična-fosfat)) je enzim sa sistematskim imenom 1-fosfatidil-1D-mio-inozitol 1,2-diacil-sn-glicerol-lijaza (formira 1D-mio-inozitol-1,2-ciklična-fosfat).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfatidilinozitolna diacilglicerol-lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 4.6.1.13 | ||||||||
| CAS broj | 37288-19-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 1-fosfatidil-1D-mio-inozitol 1D-mio-inozitol 1,2-ciklični fosfat + 1,2-diacil-sn-glicerol
Ovaj enzim je bakterijskog porekla.
Reference uredi
- ↑ Allan, D. and Michell, R.H. (1974). „Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes”. Activity at pH5.5 and pH7.0. Biochem. J. 142: 591-597. PMID 4377210.
- ↑ Friedel, R.O., Brown, J.D. and Durell, J. (1967). „Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain”. Biochim. Biophys. Acta 144: 684-686. PMID 4294905.
- ↑ Irvine, R.F. (1982). „The enzymology of stimulated inositol lipid turnover”. Cell Calcium 3: 295-309. PMID 6297738.
- ↑ Michell, R.H. and Allan, D. (1975). „Inositol cyclic phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus)”. FEBS Lett. 53: 302-304. PMID 236918.
- ↑ Low, M.G. and Finean, J.B. (1977). „Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C”. Biochem. J. 167: 281-284. PMID 588258.
- ↑ Henner, D.J., Yang, M., Chen, E., Helmikss, R. and Low, M.G. (1988). „Sequence of the Bacillus thuringiensis phosphatidylinositol-specific phospholipase C”. Nucleic Acids Res. 16: 10383-10383. PMID 3194218.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.