Fosfatidilinozitol-3,4,5-trisfosfatna 3-fosfataza
Fosfatidilinozitol-3,4,5-trisfosfatna 3-fosfataza (EC 3.1.3.67, PTEN, MMAC1, fosfatidilinozitol-3,4,5-trisfosfat 3-fosfohidrolaza) je enzim sa sistematskim imenom 1-fosfatidil-1D-mio-inozitol-3,4,5-trisfosfat 3-fosfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfatidilinozitol-3,4,5-trisfosfatna 3-fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.67 | ||||||||
| CAS broj | 210488-47-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 1-fosfatidil-1D-mio-inozitol 3,4,5-trisfosfat + H2O 1-fosfatidil-1D-mio-inozitol 4,5-bisfosfat + fosfat
Za rad ovog enzim je neophodan Mg2+.
Reference uredi
- ↑ Kabuyama, Y., Nakatsu, N., Homma, Y., Fukui, Y. (1996). „Purification and characterization of phosphatidyl inositol-3,4,5-trisphosphate phosphatase in bovine thymus”. Eur. J. Biochem. 238: 350-356. PMID 8681945.
- ↑ Maehama, T. and Dixon, J.E. The tumor suppressor, PTEN (1998). „/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate”. J. Biol. Chem. 273: 13375-13378. PMID 9593664.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.