Epi-izozizaen 5-monooksigenaza
Epi-izozizaen 5-monooksigenaza (EC 1.14.13.106, CYP170A1) je enzim sa sistematskim imenom (+)-epi-isozizaen,NADPH:kiseonik oksidoreduktaza (5-hidroksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Epi-izozizaen 5-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.106 | ||||||||
| CAS broj | 1207718-51-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (+)-epi-izozizaen + 2 NADPH + 2 H+ + 2 O2 albaflavenon + 2 NADP+ + 3H2O (sveukupna reakcija)
- (1a) (+)-epi-isozizaen + NADPH + H+ + O2 (5S)-albaflavenol + NADP+ +H2O
- (1b) (5S)-albaflavenol + NADPH + H+ + O2 albaflavenon + NADP+ + 2H2O
- (2a) (+)-epi-isozizaen + NADPH + H+ + O2 (5R)-albaflavenol + NADP+ +H2O
- (2b) (5R)-albaflavenol + NADPH + H+ + O2 albaflavenon + NADP+ + 2H2O
Ovaj enzim je citohrom-P450 enzim, iz zemljišnih bakterija Streptomyces coelicolor A3. On katalizuje dve sekvencijalne alilne oksidacione reakcije.
Reference uredi
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.