Homoserin dehidrogenaza
(Preusmjereno sa stranice EC 1.1.1.3)
Homoserin dehidrogenaza (EC 1.1.1.3, homoserinska dehidrogenaza, HSDH, HSD) je enzim sa sistematskim imenom L-homoserin:NAD(P)+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Homoserin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Homoserin dehidrogenaza homotetramer, Thiobacillus denitrificans | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.3 | ||||||||
| CAS broj | 9028-13-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- L-homoserin + NAD(P)+ L-aspartat 4-semialdehid + NAD(P)H + H+
Enzim kvasca deluje najbrže sa NAD+, dok enzim iz neurospora koristi NADP+. Enzim iz Escherichia coli je multi-funkcionalni protein, koji takođe katalizuje reakciju aspartat kinaze (EC 2.7.2.4).
Reference uredi
- ↑ Black, S. and Wright, N.G. (1955). „Homoserine dehydrogenase”. J. Biol. Chem. 213: 51-60. PMID 14353905.
- ↑ Starnes, W.L., Munk, P., Maul, S.B., Cunningham, G.N., Cox, D.J. and Shive, W. (1972). „Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex”. Biochemistry 11: 677-687. PMID 4551091.
- ↑ Véron, M., Falcoz-Kelly, F. and Cohen, G.N. (1972). „The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain”. Eur. J. Biochem. 28: 520-527. PMID 4562990.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.