Dugolančana-acil-KoA dehidrogenaza
Dugolančana-acil-KoA dehidrogenaza (EC 1.3.99.13, palmitoil-KoA dehidrogenaza, palmitoil-koenzim A dehidrogenaza, dugolančani acil-koenzim A dehidrogenaza, dugolančani-acil-KoA:(akceptor) 2,3-oksidoreduktaza) je enzim sa sistematskim imenom dugolančana-acil-KoA:akceptor 2,3-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dugolančana-acil-KoA dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.99.13 | ||||||||
| CAS broj | 59536-74-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acil-KoA + akceptor 2,3-dehidroacil-KoA + redukovani akceptor
Ovaj enzim je flavoprotein (FAD). On formira sa flavoproteinom elektronskog transfera i EC 1.5.5.1, sistem kojim se redukuje ubihinon i drugi akceptori.
Reference uredi
- ↑ Hall, C.L., Heijkenkjold, L., Bartfai, T., Ernster, L. and Kamin, H. (1976). „Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef heart mitochondria”. Arch. Biochem. Biophys. 177: 402-414. PMID 1015826.
- ↑ Hauge, J.G., Crane, F.L. and Beinert, H. (1956). „On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. III. Palmityl CoA dehydrogenase”. J. Biol. Chem. 219: 727-733. PMID 13319294.
- ↑ Ikeda, Y., Ikeda, K.O. and Tanaka, K. (1985). „Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme”. J. Biol. Chem. 260: 1311-1325. PMID 3968063.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.