Dipeptidilna peptidaza I
Dipeptidilna peptidaza I (EC 3.4.14.1, katepsin C, dipeptidilna aminopeptidaza I, dipeptidilna transferaza, katepsin C, dipeptidilna transferaza, dipeptidna arilamidaza I, DAP I) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Dipeptidilna peptidaza I | |||||||||
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Heterododekamer katepsina C (čovjek) | |||||||||
Identifikatori | |||||||||
EC broj | 3.4.14.1 | ||||||||
CAS broj | 9032-68-2 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Odvajanje N-terminalnog dipeptida, Xaa-Yaa-Zaa-, izuzev kad je Xaa: Arg ili Lys, ili je Yaa: Zaa ili Pro
Ovaj enzim je zavistan od jona Cl-.
Reference uredi
- ↑ Planta, R.J., Gorter, J. and Gruber, M. (1964). „The catalytic properties of cathepsin C”. Biochim. Biophys. Acta 89: 511-519. PMID 14209333.
- ↑ Metrione, R.M., Neves, A.G. and Fruton, J.S. (1966). „Purification and properties of dipeptidyl transferase (cathepsin C)”. Biochemistry 5: 1597-1604. PMID 5961281.
- ↑ McDonald, J.K., Zeitman, B.B., Reilly, T.J. and Ellis, S. (1969). „New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I) including the degradation of β-corticotropin and other peptide hormones”. J. Biol. Chem. 244: 2693-2709. PMID 4306035.
- ↑ McDonald, J.K. and Schwabe, C. (1977). „Intracellular exopeptidases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 311-391.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- McDonald, J.K. and Schwabe, C. (1977). „Intracellular exopeptidases”. u: Barrett, A.J.. Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.. str. 311-391.