Dimetilglicin

Dimetilglicin
	2-(Dimetilamino)sirćetna kiselina
Drugi nazivi	N,N-Dimetilglicin
Identifikacija
CAS registarski broj	1118-68-9
PubChem	673
ChemSpider	653
EINECS broj	214-267-8
DrugBank	DB02083
KEGG	C01026
MeSH	dimethylglycine
ChEBI	17724
RTECS registarski broj toksičnosti	MB9865000
Bajlštajn	1700261
Gmelin Referenca	82215
3DMet	B00224
Jmol-3D slike	Slika 1; Slika 2
SMILES
	CN(C)Cc(:[o]):[oH] CN(C)CC(O)=O
InChI
	InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7) ; Kod: FFDGPVCHZBVARC-UHFFFAOYSA-N
Svojstva
Molekulska formula	C4H9NO2
Molarna masa	103.12 g mol−1
Agregatno stanje	Beli kristali
Miris	Bez mirisa
Tačka topljenja	178-182 °C, 451-455 K, 352-360 °F
Opasnost
LD50	>650 mg kg−1 (oralno, pacov)
Srodna jedinjenja
Srodna alkanoinske kiseline	Sarkozin; Glikociamin; Kreatin; N-Metil-D-aspartinska kiselina; beta-Metilamino-L-alanin; Guanidinopropionska kiselina;
Srodna jedinjenja	Dimetilacetamid
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Dimetilglicin (DMG) je derivat aminokiseline glicina sa strukturnom formulom (CH₃)₂NCH₂COOH. On je prisutan u pasulju i jetri. On se može formirati iz trimetilglicina nakon gubitka jedne od njegovih metil grupa. On je takođe nusproizvod metabolizma holina.

Upotrebe uredi

Dimetilglicin je predložen za moguću primenu kao sredstvo za poboljšanje atletske performance, imunostimulant, i za tretman autizma, epilepsije, i mitohondrijalne bolesti.^[6]^[7] Objavljene studije su pokazale da nema znatne razlike imeđu tretmana autiyma DMG-om i placebom.^[8]^[9]

Reference uredi

↑ „dimethylglycine - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004.. Identification. Pristupljeno 24. 4. 2012.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ „Dimethylglycine”. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. 8. 12. 2009..
↑ Chinnery P, Majamaa K, Turnbull D, Thorburn D (2006). „Treatment for mitochondrial disorders”. Cochrane Database of Systematic Reviews (Online) (1): CD004426. DOI:10.1002/14651858.CD004426.pub2. PMID 16437486.
↑ Bolman WM, Richmond JA (June 1999). „A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder”. Journal of Autism and Developmental Disorders 29 (3): 191–4. PMID 10425581.
↑ Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). „Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder”. Journal of Child Neurology 16 (3): 169–73. PMID 11305684.

Spoljašnje veze uredi

Portal Hemija

[1] „dimethylglycine - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004.. Identification. Pristupljeno 24. 4. 2012.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[6] „Dimethylglycine”. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. 8. 12. 2009..

[Chinnery2006-7] Chinnery P, Majamaa K, Turnbull D, Thorburn D (2006). „Treatment for mitochondrial disorders”. Cochrane Database of Systematic Reviews (Online) (1): CD004426. DOI:10.1002/14651858.CD004426.pub2. PMID 16437486.

[8] Bolman WM, Richmond JA (June 1999). „A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder”. Journal of Autism and Developmental Disorders 29 (3): 191–4. PMID 10425581.

[9] Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). „Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder”. Journal of Child Neurology 16 (3): 169–73. PMID 11305684.

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