Dijodotirozin transaminaza
Dijodotirozin transaminaza (EC 2.6.1.24, dijodotirozinska aminotransferaza, halogenisani tirozin aminotransferaza, halogenisani tirozin transaminaza) je enzim sa sistematskim imenom 3,5-dijodo-L-tirozin:2-oksoglutarat aminotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dijodotirozin transaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.24 | ||||||||
| CAS broj | 9033-18-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3,5-dijodo-L-tirozin + 2-oksoglutarat 4-hidroksi-3,5-dijodofenilpiruvat + L-glutamat
Ovaj enzim je piridoksal-fosfatni protein. On takođe deluje na 3,5-dihloro-, 3,5-dibromo- i 3-jodo-L-tirozin, tiroksin i trijodotironin.
Reference uredi
- ↑ Nakano, M. (1967). „Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria”. J. Biol. Chem. 242: 73-81. PMID 4381052.
- ↑ Nakano, M. and Danowski, T.S. (1964). „Thyroid-hormone transaminase and oxidase in rat-kidney mitochondria”. Biochim. Biophys. Acta 85: 18-28. PMID 14159298.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.