Dihidroorotaza
Dihidroorotaza (EC 3.5.2.3, karbamoilaspartinska dehidraza, dihidroorotatna hidrolaza) je enzim sa sistematskim imenom (S)-dihidroorotat amidohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dihidroorotaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Dihidroorotaza dimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.5.2.3 | ||||||||
| CAS broj | 9024-93-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (S)-dihidroorotat + H2O N-karbamoil-L-aspartat
Reference uredi
- ↑ Cooper, C. and Wilson, D.W. (1954). „Biosynthesis of pyrimidines”. Fed. Proc. 13: 194-194.
- ↑ Lieberman, I. and Kornberg, A. (1954). „Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. II. Dihydroorotic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin”. J. Biol. Chem. 207: 911-924. PMID 13163076.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.