Difosfoinozitol-polifosfatna difosfataza
Difosfoinozitol-polifosfatna difosfataza (EC 3.6.1.52, difosfoinozitol-polifosfatna fosfohidrolaza, DIPP) je enzim sa sistematskim imenom difosfo-mio-inozitol-polifosfat difosfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Difosfoinozitol-polifosfatna difosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.52 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- difosfo-mio-inozitol polifosfat + H2O mio-inozitol polifosfat + fosfat
Ovaj enzim hidrolizuje difosfatnu vezu.
Reference uredi
- ↑ Safrany, S.T., Caffrey, J.J., Yang, X., Bembenek, M.E., Moyer, M.B., Burkhart, W.A. and Shears, S.B. (1998). „A novel context for the 'MutT′ module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase”. EMBO J. 17: 6599-6607. PMID 9822604.
- ↑ Caffrey, J.J., Safrany, S.T., Yang, X. and Shears, S.B. (2000). „Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family”. J. Biol. Chem. 275: 12730-12736. PMID 10777568.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.