Dekaprenil-fosfat fosforiboziltransferaza
Dekaprenil-fosfat fosforiboziltransferaza (EC 2.4.2.45, 5-fosfo-alfa-D-riboza-1-difosfat:dekaprenil-fosfat 5-fosforiboziltransferaza, 5-fosfo-alfa-D-riboza 1-pirofosfat:dekaprenil fosfat 5-fosforiboziltransferaza, DPPR sintaza, Rv3806) je enzim sa sistematskim imenom trans,oktacis-dekaprenilfosfo-beta-D-ribofuranoza 5-fosfat:difosfat fosfo-alfa-D-riboziltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
Dekaprenil-fosfat fosforiboziltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.4.2.45 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- trans,oktacis-dekaprenil fosfat + 5-fosfo-alfa-D-riboza 1-difosfat trans,oktacis-dekaprenilfosfo-beta-D-ribofuranoza 5-fosfat + difosfat
Za rad ovog enzima je neophodan Mg2+. Izolovan je iz Mycobakterija tuberculosis.
Reference uredi
- ↑ Huang, H., Scherman, M.S., D'Haeze, W., Vereecke, D., Holsters, M., Crick, D.C. and McNeil, M.R. (2005). „Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-α-D-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-D-arabinose synthesis”. J. Biol. Chem. 280: 24539-24543. PMID 15878857.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.