LY-307,452
(Preusmjereno sa stranice DWLOVDOPFJPWNE-HKUYNNGSSA-N)
LY-307,452 je lek koji se koristi u naučnim istraživanjima. On je bio među prvim jedinjenjima koja su delovala kao selektivni antagonisti za grupu II metabotropnih glutamatnih receptora (mGluR2/3),[3] i bio je koristan u ranim ispitivanjima te receptorske familije,[4][5] mada je u međuvremenu uglavnom zamenjen novijim lekovima poput LY-341,495.
(IUPAC) ime | |||
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(2S,4S)-2-amino-4-(4,4-difenilbut-1-il)pentan-1,5-dioiska kiselina | |||
Klinički podaci | |||
Identifikatori | |||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 6324634 | ||
Hemijski podaci | |||
Formula | C21H25NO4 | ||
Mol. masa | 355,428 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD (February 1996). „(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase”. Journal of Medicinal Chemistry 39 (4): 814–6. DOI:10.1021/jm9508144. PMID 8632404.
- ↑ Li XC, Beart PM, Monn JA, Jones NM, Widdop RE (October 1999). „Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats”. British Journal of Pharmacology 128 (3): 823–9. DOI:10.1038/sj.bjp.0702850. PMC 1571690. PMID 10516668.
- ↑ Sung KW, Choi S, Lovinger DM (November 2001). „Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses”. Journal of Neurophysiology 86 (5): 2405–12. PMID 11698530.